Valérie Suain Selected Research

Alzheimer Disease (Alzheimer's Disease)

1/2020	Picalm reduction exacerbates tau pathology in a murine tauopathy model.
1/2020	The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease.
1/2019	Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo.
1/2017	Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model.
10/2016	Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
1/2015	Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice.
12/2012	Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.
1/2012	Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.

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Valérie Suain Research Topics

Disease

8	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2012
6	Tauopathies 01/2020 - 01/2014
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 10/2016
2	Amyloid Plaque 01/2020 - 01/2017
2	Frontotemporal Dementia (Semantic Dementia) 01/2019 - 10/2015
1	Hyponatremia 11/2023
1	Demyelinating Diseases (Demyelinating Disease) 11/2023
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2020
1	Inflammation (Inflammations) 01/2019
1	Down Syndrome (Down's Syndrome) 10/2016
1	Pick Disease of the Brain (Pick's Disease) 10/2016
1	Genetic Predisposition to Disease (Genetic Predisposition) 10/2016
1	Contusions 05/2014
1	Spinal Cord Injuries (Spinal Cord Injury) 05/2014
1	Memory Disorders (Memory Loss) 12/2012
1	Acute Liver Failure (Fulminant Hepatic Failure) 10/2008
1	Hyperammonemia 10/2008
1	Hepatic Insufficiency 10/2008

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2012
5	tau Proteins (tau Protein)IBA 01/2019 - 01/2014
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 12/2012
2	Apolipoproteins E (ApoE)IBA 01/2020 - 01/2020
2	Peptides (Polypeptides)IBA 01/2017 - 01/2014
1	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 11/2023
1	SodiumIBA 11/2023
1	ADP-Ribosylation Factors (ADP-Ribosylation Factor)IBA 11/2023
1	synaptojaninIBA 01/2020
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020
1	LipidsIBA 01/2020
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2019
1	CaspasesIBA 01/2019
1	Palmitic Acid (Hexadecanoic Acid)IBA 01/2019
1	stearoyl-coenzyme A (stearoyl-CoA)IBA 01/2019
1	Beclin-1IBA 10/2016
1	Autophagy-Related ProteinsIBA 10/2016
1	ClathrinIBA 10/2016
1	temsirolimus FDA Link 01/2015
1	Green Fluorescent ProteinsIBA 05/2014
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 05/2014
1	Protein Isoforms (Isoforms)IBA 01/2014
1	Dyneins (Dynein)IBA 01/2012
1	KinesinsIBA 01/2012
1	Dacarbazine (DIC)FDA LinkGeneric 01/2012
1	OrnithineIBA 10/2008
1	Thioacetamide (Thioacetamid)IBA 10/2008
1	Carbon Tetrachloride (Tetrachloromethane)IBA 10/2008
1	AmmoniaIBA 10/2008

Therapy/Procedure

1	Denervation 10/2015